Zinc (II) protoporphyrin IX (ZnPP) strongly inhibits antioxidative enzyme heme oxygenase-1 (HO-1), and ZnPP generates reactive oxygen species (ROS) upon light irradiation. Zinc Protoporphyrin IX (Protoporphyrin IX Zinc(II), ZnPP) is a guanylate cyclase inhibitor heme oxygenase enzyme used in cancer research and other life science applications. The fraction of late apoptotic and necrotic cells increased from 10.9% in controls to 30.4% after 72 h. Exerted cystostatic/cytotoxic effects against tumor cells. [2][3] Wang, S., Hannafon, B. N., Lind, S. E., & Ding, W. Zinc protoporphyrin suppresses beta]-catenin protein expression in human cancer Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. For research use only. We do not sell to patients. Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 PathwayXinnong Liu, et al. "Zinc protoporphyrin: A metabolite with a mission", "The interpretation of zinc protoporphyrin changes in lead intoxication: a case report and review of the literature", http://beaunet.beaumont.edu/portal/pls/portal/lab.lab_pkg.lab_test_info_content?xid=862, https://en.wikipedia.org/w/index.php?title=Zinc_protoporphyrin&oldid=1051887323, Articles with unsourced statements from November 2009, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 26 October 2021, at 04:35. 1. [10] The possible negative effects on major organs were not seen and blood distribution is more desirable in ZnPP loaded nanoparticles than free ZnPP. All Rights Reserved. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Cytotoxic/tumor suppressor role of zinc for the treatment of cancer: an enigma and an opportunity. [1]. 2020 Jul 15;253:117678. Probenecid sodium is water-soluble, it can reduce the amount of β-lactam antibiotics in the compound, thereby effectively reducing bacterial resistance caused by ultra-high doses of antibiotics. Zinc protoporphyrin (ZPP) is formed in circulating red blood cells (RBC) either in the presence of lead or in the absence of sufficient iron, as both of these conditions inhibit the insertion of a ferrous ion into. Zinc protoporphyrin (ZPP) is used to monitor chronic exposure to lead in adults. Zinc protoporphyrin (ZPP) is a substance that is normally found in RBCs in trace amounts during heme synthesis. 2008 Jul 11;8:197. Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle[3]. 2014 Nov 26;12:229. Mitochonic acid 5 regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway. Explains how the zinc protoporphyrin (ZPP) test is used, when a ZPP test is requested, and what the results of a ZPP test might mean. A wide assortment of chemicals and reagents are available for use in The chemical Zinc protoporphyrin IX has a designated molecular formula of C34H32N4O4Zn and a. Kang, K. A., Maeng, Y. H., Zhang, R., Yang, Y. R., Piao, M. J., Kim, K. C., Hyun, J. W.. Involvement of heme oxygenase-1 in korean colon cancer. Not for human use. [10] Similarly ZnPP loaded into nanoparticles has a higher cytotoxicity than free ZnPP after two days due to a more favorable release rate as well as better biodistribution and internalization. [13] ZnPP works in combination with anticancer drugs to increase cytotoxicity. The fluorescent properties of ZPP in intact red cells allows the ZPP/heme molar ratio to be measured quickly, at low cost, and in a small sample volume.[6]. 2007 Feb 1;120(3):500-5. [1], Measurement of zinc protoporphyrin in red cells has been used for screening for lead poisoning. The virtue of elevated ZPP testing as a screen is that all of these conditions can be considered worth discovering. All of the co-solvents are provided by MCE. 2018 Apr 26;2018:7161592. 12.5, 25, 50 mg/kg for i.p. Zinc Protoporphyrin Recently Published Documents. ZnPP can induce lethal. CID 23994 (Zinc). Send Us Your Feedback. [15] ZnPP have been injected in a number of trials on solid tumors, but can be utilized more broadly when effectively delivered to cancer cells and not healthy cells. Based on 4 publication(s) in Google Scholar. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells[3]. Resulted in dose- and time-dependent reduction of cells in G1 phase of the cell cycle. L-Asparagine is a naturally occurring amino acid that is not an essential for humans and can be synthesized from central metabolic pathway intermediates. 2015 Sep 15;6(27):24393-403. Les porphyrines sont des pigments, dérivés tétra Les protoporphyrines érythrocytaires sont libres ou liées au zinc (protoporphyrine zinc ou PPZ) sous. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. [13] ZnPP suppression of heme oxygenase reduces cell viability of cancer cells and increases cytotoxicity in cancer cells. Thanks, your subscription has been confirmed. [10] Reducing the anti-oxidant capability of healthy cells can reduce effects that would have been favorable. J Pediatr Gastroenterol Nutr. We have received your request and will respond to you as soon as possible. Zinc-protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat. Park C, et al. Zinc protoporphyrin IX. [10] However ZnPP have been encapsulated in nanoparticles with specialized coating for drug delivery inside the body. cells: The potential involvement of lysosome-mediated degradation. Animal A (mg/kg) = Animal B (mg/kg) multiplied by. We do not sell to patients. Choose Topic. [14] ZnPP inhibits tumor growth especially solid tumors. It is a red-purple solid that is soluble in water. [1] In 1974 ZPP was identified as a major non-heme porphyrin formed in red cells as the result of lead poisoning or iron deficiency.,[7], It was already known at this time that non-heme protoporphyrin IX levels were elevated in these conditions, but prior investigators had used acidic extraction methods in their assays that converted ZPP to unbound Protoporphyrin IX. [10] Increased reactive oxidative species can cause apoptosis in cancer cells and reduce drug resistance when exposed to ZnPP due to loss of the heme oxygenase coping mechanism. BMC Cancer. Nowis D, et al. Zinc Protoporphyrin. Zinc protoporphyrin (ZPP) is used to monitor chronic exposure to lead in adults. Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL miceKaeko Hirai, et al. ; 12.5, 50 mg/kg for p.o. We do not sell to patients.© Copyright 2010-2020 AbMole BioScience. Planar zinc(II) complexes are unknown. Zinc protoporphyrin (ZPP) refers to coordination complexes of zinc and protoporphyrin IX. [10] A targeted delivery system is needed to fully exploit the uses of ZnPP as a therapeutic agent and heme oxygenase inhibitor due to the potential side effects of free ZnPP on healthy tissue. Effects of hemoglobin oxygenase-1 inhibitor zinc protoporphyrin IX on acute viral myocarditis in miceXing Rong, et al. [14] The inhibition of heme oxygenase leads to an increase of reactive oxidative species in the cell which sensitizes the cells to chemotherapeutic agents. Leaded to accumulation of cleaved (active) caspase-3. Zinc protoporphyrin completely reversed these effects. Zinc Protoporphyrin RBC. LNV3FKZ7GR. Mar Drugs. Products are for research use only. PMID: 26405158. Classification of Porphyria: Primary Porphyria. [Pg.98]. You will hear from us soon. The complex and related species are found in red blood cells when heme production is inhibited by lead and/or by lack of iron. They are for reference only. Our Zinc protoporphyrin IX is confirmed by NMR. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h[3]. Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy. CID 4971 (Protoporphyrin IX). [15] Cells treated with ZnPP and radiation as opposed to simply one of the two are less viable and more likely to stay in G1 phase of the cell cycle, rather than progress to the G2 phase. [4][1], Zinc protoporphyrin levels can be elevated as the result of a number of conditions, for instance:[2]. For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. ; 12.5, 50 mg/kg for p.o. * Please select Quantity before adding items. PMID: 18339274. Zinc Protoporphyrin has anti-cancer activity[3]. As the situation with COVID-19 continues to unfold in every community, MedChemExpress is responding to the uncertainty caused by this outbreak thoughtfully and cautiously. * Required Fields. The reduced coping ability of tissues treated with ZnPP also increases radiosensitivity. MCE has not independently confirmed the accuracy of these methods. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in miceDominika Nowis, et al. Zhonghua Er Ke Za Zhi. PMID: 29854090. Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the. Your need for high quality reagent doesn't stop during difficult times, and neither do we. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan preschool children: a community-based. A ZPP level can be. -20°C, sealed storage, away from moisture, *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture), DMSO : 50 mg/mL (79.87 mM; Need ultrasonic), Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline, Solubility: ≥ 2.5 mg/mL (3.99 mM); Clear solution, Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline), Solubility: 2.5 mg/mL (3.99 mM); Suspended solution; Need ultrasonic. 2014 Nov 26;12:229. Zinc protoporphyrin in blood After 1 month exposure 2 50 pg/100 ml erythrocytes or lOOpg/IOOmI blood B. [2]. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2]. Except where otherwise noted, data are given for materials in their, Some reports, for instance, measured the ZPP/Heme molar ratio (μmole ZPP per mole of heme), but reported this as the weight concentration (μg of EP per deciliter of packed red cells, or μg of EP per g hemoglobin at an. [1][4], ZnPP has been investigated for cancer therapies. BMC Med. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc protoporphyrin inhibits CO production in rats. Zinc Protoporphyrin is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Non-invasive Diagnostics of Iron Deficiency in Surgical Patients by Measuring Zinc Protoporphyrin-IX. If you need to change the delivery plan for items ordered, please contact us via email [email protected]. BMC Med. [10] ZnPP did not show any reduce inhibitory potential on heme oxygenase when loaded into nanoparticles. Mwangi MN, et al. Component Compounds. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. ZPP is also abbreviated ZP and ZnPP. BMC Cancer. BMC Cancer. Crucial role of heme oxygenase-1 on the sensitivity of cholangiocarcinoma cells to chemotherapeutic agents. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Products are chemical reagents for research use only and are not intended for human use. Room temperature in continental US; may vary elsewhere. [10] [11][12], ZnPP is a competitive inhibitor of heme oxygenase. ; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth[3]. Thank you for being a loyal MedChemExpress customer, we are here to assist you as needed. Definition. Heme oxygenase-1 accelerates erastin-induced ferroptotic cell deathMin-Young Kwon, et al. PNPG (4-Nitrophenyl-β-D- glucopyranoside) is a chromogenic β-D-glucosidase substrate, producing a yellow solution upon cleavage. The complex and related species are found in red blood cells when heme production is inhibited by lead and/or by lack of iron. PMID: 18620555. Kongpetch, S., Kukongviriyapan, V., Prawan, A., Senggunprai, L., Kukongviriyapan, U., & Buranrat, B. Mar Drugs. 2019 Apr 13;17(4). Zinc protoporphyrin. Zinc Protoporphyrin has anti-cancer activity. Yin, H., Fang, J., Liao, L., Maeda, H., & Su, Q. Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity. PMID: 17066448. Your information is safe with us. Related terms: Iron Deficiency. zinc protoporphyrin CAS 15278-20-3 WIKI information includes physical and chemical properties, USES, security data, NMR spectroscopy, computational chemical data and more. It is also elevated in iron deficiency and maybe ordered to help detect this deficiency in children. [14] Tumors from brain cancer, colon cancer, prostate cancer, renal cell cancer, oral squamous cell cancer, and leukemia all show a susceptibility to ZnPP due to increase expression of heme oxygenase. Zinc porphyrins are always five- or six-coordinate. Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth. q Zinc protoporphyrin, in RBC Material: 3 ml EDTA blood TAT: 7-10 days* Method: HPLC Units: μg/g Hb. Current practice is tending to measure and report the molar ratio of ZPP to heme (μmole/mole). [15] ZnPP and radiation combination therapy shows more apoptosis than the same amount of radiation displaying that ZnPP puts stress on cancerous tissue. If you have published this work, please enter the PubMed ID. Please refer to the solubility information to select the appropriate solvent. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg. [12] Heme oxygenase is a cytoprotective enzyme that copes with oxidative stress on a cell and shows higher expression in cancerous tissues. Porphyrin complexes of zinc have been known since the 1930s. 2019 Apr 13;17(4). [8], The early literature is sometimes confusing, and results are hard to compare without detailed examination of the measurement methods and the conversion factors used to report the results. Sorry, but the email address you supplied was invalid. Zinc protoporphyrin IX. [3]. ZnPP is finding a new use as a drug in combined cancer therapies. [9] Reports may refer to free erythrocyte protoporphyrin (FEP) or erythrocyte protoporphyrin (EP or EPP). 2008 Jul 11;8:197. We will send it to your Email address shortly. Heme oxygenase and guanylyl cyclase inhibitor CAS# 15442-64-5. [10] The specific inhibition of heme oxygenase using nanoparticles with encapsulated ZnPP reduces side effects and is likely the future method of administering ZnPP treatment.[10]. Protoporphyrine zinc. Dietary zinc availability of zinc protoporphyrin IX (ZnPP), which mainly contributes to the color of dry-cured meat products, was examined in rats fed a low-zinc diet (5ppm Zn). PMID: 32376267. Park C, et al. Mwangi MN, et al. 2007 Dec;45(12):893-7. Oncotarget. We're doing our best to keep everyone healthy and safe in the workplace while also avoiding the interruptions to our day-to-day operations. Please fill out this form to request the QC report. Chitin is a large, structural polysaccharide found in the cell walls of fungi, the exoskeletons of insects, and certain hard structures in fish and invertebrates. Buy Zinc Protoporphyrin (ZnPP) from AbMole BioScience. and for iron deficiency. Oxid Med Cell Longev. Heme oxygenase-1 alleviated non-alcoholic fatty liver disease via suppressing ROS-dependent endoplasmic reticulum stressDongdong Li, et al. Int J Cancer. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. Life Sci. [14] The combination of these two therapies is highly effective in treating cancer in experiments thus far, and is a possible new method for overcoming drug resistance. When the zinc protoporphyrin level is used to assess the lead in the blood level, the analytical accuracy of the ZPP and the PbB determinations should be known. Background: Zinc protoporphyrin (ZPP) has been used to screen and manage iron deficiency in individual children, but it has also been recommended to assess population iron status. Because the axial ligands are labile, these complexes are often depicted with planar structures. Order now can get a discount! Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol), Concentration (start) × Volume (start) = Concentration (final) × Volume (final), This equation is commonly abbreviated as: C1V1 = C2V2, Zinc Protoporphyrin15442-64-5Zn(II)-protoporphyrin IX ZnPP Zinc Protoporphyrin-9Zinc Protoporphyrin9Zinc Protoporphyrin 9Zinc Protoporphyrin-9Reactive Oxygen SpeciesEndogenous MetaboliteApoptosishemeoxygenase-1HO-1PhloroglucinolH2O2screeningmarkerirondeficiency,anti-cancerInhibitorinhibitorinhibit. These findings were further confirmed in vitro, using Caco-2 cells with gain- or. Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3[3]. (Synonyms: Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9). Also the variability of lead. It is a red-purple solid that is soluble in water. Zhang, W., Qiao, T., & Zha, L. Inhibition of heme oxygenase-1 enhances the radiosensitivity in human nonsmall cell lung cancer A549 cells. Human Endogenous Metabolite Compound Library, Anti-Cardiovascular Disease Compound Library. Nowis D, et al. Rouhani, H., Sepehri, N., Montazeri, H., Khoshayand, M. R., Ghahremani, M. H., Ostad, S. N., Dinarvand, R. Zinc protoporphyrin polymeric. Submission failed, please try again later. 2008 Jul 11;8:197. Zinc Protoporphyrin. Zinc Protoporphyrin is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc protoporphyrin (ZPP) refers to coordination complexes of zinc and protoporphyrin IX.
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